- CDH1 / E Cadherin Recombinant Monoclonal Antibody
- LSBio
- Pricing InfoSupplier PageView Company Product Page
- LS-B16237
- Human (Hu)
- WB, IF, IHC-p
- rCDH1/1525
- Unconjugated
- Protein A/G purified
- cadherin 1
- Arc-1, BCDS1, CD324, CDHE, ECAD, LCAM, UVO
- Recombinant Monoclonal
- IgG1
- 10 mM PBS, 0.05% BSA, 0.05% Sodium Azide
- Mouse
- CDH1 / E Cadherin
- 100 µg
Specifications/Features
Specificity: Recognizes a protein of 120-80 kDa, identified as E-cadherin. Cadherins comprise a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. The classical cadherins, E-, N- and P-cadherin, consist of large extracellular domains characterized by a series of five homologous NH2 terminal repeats. The relatively short intracellular domains interact with a variety of cytoplasmic proteins, such as beta-catenin, to regulate cadherin function. E-cadherin plays an important role in epithelial cell adhesion. A decreased expression of E-cadherin is associated with metastatic potential and poor prognosis in breast cancer, prostate and esophageal cancer. In combination with p120 Catenin, it is useful for the differentiation between ductal (E-cadherin +) and lobular (E-cadherin -) breast carcinomas. It may also help in diagnosis of mesothelioma